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Product details
Cat#：187P09
Three Letter Code: H-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH₂ trifluoroacetate salt
One Letter Code: YELLHGAGNHAAGILTL
Synonyms: Hypocretin-1 (17-33)
Molecular Formula: C₇₉H₁₂₅N₂₃O₂₂
Relative Molecular Mass: 1749
CAS#: 343268-91-7
Source: Synthetic
Storage Conditions: -20 ± 5 °C
Areas of Interest: Obesity Research
Details: Orexin A (17-33) acts as selective OX1 antagonist. Truncation studies have led to OXA (17-33) as the shortest active peptide known to date with a 23-fold selectivity for OX1 over OX2. The native orexins A and B do not show distinct receptor selectivity. Both OX receptors are involved in energy homeostasis and the sleep/wake cycle, hence selective as well as dual antagonists are required for research.
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